Table 2.
Stability of daptomycin in lactated Ringer's solution with heparin
| Heparin concn (U/ml) | Daptomycin concn (mg/ml) (% of initial value) with storage duration (h) of: |
||||
|---|---|---|---|---|---|
| 0 | 4 | 6 | 12 | 24 | |
| 0 | 5.1 (100) | 4.9 (97) | 4.9 (97) | 4.8 (95) | 4.6 (90) |
| 5 | 5.1 (100) | 5.0 (99) | 5.0 (99) | 4.9 (96) | 4.6 (90) |
| 500 | 5.1 (100) | 5.0 (99) | 5.0 (98) | 4.9 (96) | 4.6 (90) |
| 5,000 | 5.1 (100) | 5.1 (99) | 5.0 (98) | 5.0 (96) | 4.7 (91) |
| 0 | 26.8 (100) | 26.5 (99) | 26.0 (97) | 25.4 (95) | 24.0 (90) |
| 5 | 26.3 (100) | 26.3 (100) | 26.1 (99) | 25.3 (96) | 23.9 (91) |
| 500 | 26.3 (100) | 26.2 (100) | 26.1 (99) | 25.2 (96) | 24.2 (92) |
| 5,000 | 27.1 (100) | 26.6 (98) | 26.8 (99) | 25.1 (92) | 24.6 (90) |