Table 1.
Sequencing and drug susceptibility results of 74 MTBC strainsa
| Sample | Genotypeb | SNP(s) (uppercase in codons) and resulting mutation(s) in: |
Drug susceptibility test resultc |
||
|---|---|---|---|---|---|
| mshA (Rv0486) | inhA (Rv1484) | PRO | INH | ||
| 12594/02 | Beijing | gCa/gTa A187V | |||
| 1500/03 | Beijing | gCa/gTa A187V | ND | ||
| 1934/03 | Beijing | gCa/gTa A187V | ND | ||
| 3256/02 | Beijing | gCa/gTa A187V | R | R | |
| 3329/02 | Beijing | gCa/gTa A187V | R | ||
| 4445/02 | Beijing | gCa/gTa A187V | R | ||
| 1417/02 | Cameroon | ||||
| 1428/02 | Cameroon | ||||
| 5390/02 | Cameroon | ND | |||
| 5400/02 | Cameroon | ND | |||
| 1797/03 | EAI | ||||
| 4850/03 | EAI | gGg/gCg G106A, gAc/gCc D218A | |||
| 947/01 | EAI | ||||
| 10459/03 | Euro-American | ||||
| 12591/02 | Euro-American | ||||
| 8870/03 | Euro-American | R | |||
| 10469/01 | Ghana | R | R | ||
| 10493/01 | Ghana | R | |||
| 2570/02 | Ghana | ||||
| 9679/00 | H37Rv ATCC 27294 | ||||
| 2336/02 | Haarlem | aAc/aGc N111S | |||
| 9532/03 | Haarlem | aAc/aGc N111S | |||
| 4130/02 | Haarlem | aAc/aGc N111S | |||
| 1449/02 | M. africanum 1a | ||||
| 1473/02 | M. africanum 1a | ||||
| 5434/02 | M. africanum 1a | ND | |||
| 10473/01 | M. africanum 1b | ND | |||
| 10494/01 | M. africanum 1b | ||||
| 1443/02 | M. africanum 1b | ||||
| 5432/02 | M. africanum 1b | ND | R | ||
| 10476/01 | M. africanum 2 | Cta/Tta L261L | gTg/gCg V78A | R | |
| 10514/01 | M. africanum 2 | gTg/gCg V78A | R | ||
| 10517/01 | M. africanum 2 | gTg/gCg V78A | |||
| 5468/02 | M. africanum 2 | gTg/gCg V78A | ND | ||
| 9550/00 | M. africanum 2 ATCC 25420 | gTg/gCg V78A | |||
| 4258/00 | M. bovis | ND | |||
| 751/01 | M. bovis | ||||
| 7540/01 | M. bovis | ND | |||
| 9564/00 | M. bovis ATCC 19210 | Ggg/Agg G106R | |||
| 3040/99 | M. canettii | ggG/ggC G106G, gaC/gaT D208D | ggT/ggC G205G | ||
| 3041/99 | M. canettii | −132C/A,d ggG/ggC G106G | ggT/ggC G205G | ||
| 3151/08 | M. canettii | −132C/A,d ggG/ggC G106G | ggT/ggC G205G | ND | |
| 1694/00 | M. caprae | ||||
| 8986/99 | M. caprae | ND | |||
| 9577/99 | M. caprae | ||||
| 416/01 | M. microti llama | ND | |||
| 1479/00 | M. microti vole | ND | |||
| 8753/00 | M. microti llama | ||||
| 7011/02 | M. pinnipedii seal | Ccg/Tcg P107S | |||
| 7739/01 | M. pinnipedii seal | Ccg/Tcg P107S | |||
| 10264/03 | Tur | Ctg/Ttg L244L | |||
| 10529/03 | Tur | Ctg/Ttg L244L | |||
| 11313/03 | Tur | Ctg/Ttg L244L | |||
| 2169/99 | Uganda I | ND | |||
| 2201/99 | Uganda I | ND | R | ||
| 2333/99 | Uganda I | ctC/ctT L88L | ND | ||
| 2176/99 | Uganda II | ND | |||
| 2191/99 | Uganda II | ctC/ctT L88L | ND | ||
| 2253/99 | Uganda II | ND | |||
| 4412/04 | X-type | ||||
| 8431/05 | X-type | ND | |||
| 9953/04 | X-type | ||||
a
Strains with no data listed were susceptible, and the wild-type sequence was detected; strains of the following genotypes which were sensitive to both PRO and INH and did not harbor any mutations are not listed: Delhi/CAS (samples 2637/02, 7936/01, and 7507/01), LAM (samples 7968/03, 8885/03, and 946/03), S-type (samples 2151/03, 2318/06, and 6411/05), and Ural (samples 1657/03, 8431/03, and 2679/03).
b
CAS, Central Asian; EAI, East African Indian; LAM, Latin American Mediterranean.
c
PRO, prothionamide; INH, isoniazid; R, resistant; ND, not determined.
d
Leads to synonymous ctC/ctA L411L change in Rv0485.