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Replacement of the genotype 1b β-hairpin sequence in NS5B with that of genotype 2a (amino acids 435 to 455) significantly reduces replicon susceptibility to GS-9190. The antiviral phenotype of chimeric replicons was assessed in transiently transfected Huh7-Lunet cells and analyzed 72 h post-inhibitor addition. EC50s shown are averages of at least two independent experiments, each carried out in duplicate.
