Table 1.
In vitro susceptibility to finafloxacin and other fluoroquinolones under standard testing conditions and at slightly acidic pH
| Organism | Susceptibility to ciprofloxacina | No. of isolates tested | Antibiotic | MIC (mg/liter) at:b |
|||||
|---|---|---|---|---|---|---|---|---|---|
| pH 7.2–7.4 |
pH 5.8–6.2 |
||||||||
| Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | ||||
| Community-associated MRSA | Susceptible | 33 | Finafloxacin | 0.125–0.25 | 0.125 | 0.25 | 0.06–0.125 | 0.06 | 0.125 |
| Ciprofloxacin | 0.25–1 | 0.5 | 1 | 1–4 | 1 | 4 | |||
| Moxifloxacin | 0.03–0.125 | 0.06 | 0.125 | 0.25–0.5 | 0.25 | 0.5 | |||
| Staphylococcus aureus | Resistant | 30 | Finafloxacin | 0.25–32 | 2 | 16 | 0.25–32 | 1 | 4 |
| Ciprofloxacin | 4–>64 | 32 | >64 | 16–>64 | 32 | >64 | |||
| Levofloxacin | 4–>64 | 2 | 32 | 4–>64 | 16 | >64 | |||
| Moxifloxacin | 2–32 | 2 | 32 | 0.5–64 | 8 | 32 | |||
| Coagulase-negative staphylococcus | Susceptible | 26 | Finafloxacin | 0.015–0.5 | 0.25 | 0.5 | 0.008–1 | 0.06 | 0.125 |
| Ciprofloxacin | 0.06–1 | 0.25 | 0.5 | 0.125–4 | 0.5 | 1 | |||
| Resistant | 16 | Finafloxacin | 0.06–>16 | 8 | 16 | 0.125–16 | 1 | 16 | |
| Ciprofloxacin | 2–>16 | >16 | >16 | 8–>16 | >16 | >16 | |||
| Streptococcus pneumoniae | Mixed | 21 | Finafloxacin | 0.5–4 | 1 | 2 | ND | ND | ND |
| Ciprofloxacin | 1–4 | 2 | 4 | ND | ND | ND | |||
| Levofloxacin | 0.5–2 | 1 | 2 | ND | ND | ND | |||
| Moxifloxacin | 0.125–0.5 | 0.5 | 1 | ND | ND | ND | |||
| Streptococcus pyogenes | Susceptible | 22 | Finafloxacin | 0.25–1 | 0.5 | 0.5 | 0.125–0.5 | 0.25 | 0.25 |
| Ciprofloxacin | 0.125–1 | 0.5 | 1 | 0.25–2 | 1 | 2 | |||
| Moxifloxacin | 0.125–0.5 | 0.25 | 0.25 | 0.25–1 | 0.5 | 0.5 | |||
| Streptococcus agalactiae | Mixed | 11 | Finafloxacin | 0.5–4 | 1 | 2 | 0.125–4 | 0.25 | 0.5 |
| Ciprofloxacin | 0.5–4 | 1 | 2 | 0.5–4 | 1 | 2 | |||
| Enterococcus faecalis | Mixed | 10 | Finafloxacin | 0.5–32 | 1 | 32 | 0.25–16 | 0.5 | 16 |
| Ciprofloxacin | 0.5–128 | 1 | 64 | 2–>256 | 4 | >256 | |||
| Enterococcus faecium | Mixed | 9 | Finafloxacin | 1–128 | NC | NC | 0.5–32 | NC | NC |
| Ciprofloxacin | 1–256 | NC | NC | 2–>256 | NC | NC | |||
| Escherichia coli | Resistant | 75 | Finafloxacin | 16–>256 | 128 | 256 | 2–64 | 8 | 32 |
| Ciprofloxacin | 8–>256 | 128 | >256 | >256 | >256 | >256 | |||
| Levofloxacin | 8–128 | 32 | 64 | 32–>256 | 256 | >256 | |||
| Susceptible | 12 | Finafloxacin | 0.03–1 | 0.125 | 0.25 | ≤0.008–0.125 | 0.016 | 0.03 | |
| Ciprofloxacin | ≤0.008–0.125 | 0.016 | 0.03 | 0.06–2 | 0.125 | 0.25 | |||
| Klebsiella spp. | Susceptible | 16 | Finafloxacin | 0.06–4 | 0.25 | 2 | 0.008–1 | 0.06 | 0.5 |
| Ciprofloxacin | 0.016–1 | 0.03 | 0.5 | 0.125–8 | 0.5 | 8 | |||
| Resistant | 7 | Finafloxacin | 2–>32 | NC | NC | 0.5–>32 | NC | NC | |
| Ciprofloxacin | 2–>16 | NC | NC | 8–>16 | NC | NC | |||
| Salmonella spp. | Mixed | 8 | Finafloxacin | 0.5–16 | NC | NC | 0.06–4 | NC | NC |
| Ciprofloxacin | 0.125–32 | NC | NC | 1–>32 | NC | NC | |||
| Levofloxacin | 0.25–16 | NC | NC | 0.5–>32 | NC | NC | |||
| Moxifloxacin | 0.25–16 | NC | NC | 1–>32 | NC | NC | |||
| Proteus mirabilis | Mixed | 10 | Finafloxacin | 0.5–>32 | 1 | 16 | 0.06–8 | 0.25 | 4 |
| Ciprofloxacin | ≤0.008–1 | 0.016 | 1 | 0.06–>16 | 0.125 | 8 | |||
| Providencia spp. | Mixed | 11 | Finafloxacin | 0.06–16 | 8 | 16 | ≤0.03–8 | 1 | 8 |
| Ciprofloxacin | ≤0.03–16 | 1 | 4 | 0.125–>16 | 16 | >16 | |||
| Levofloxacin | ≤0.03–16 | 1 | 2 | 0.06–>16 | 8 | >16 | |||
| Moxifloxacin | ≤0.03–16 | 0.5 | 2 | 0.125–>16 | 8 | >16 | |||
| Enterobacter spp. | Susceptible | 10 | Finafloxacin | 0.06–0.5 | 0.125 | 0.125 | ≤0.03–0.125 | ≤0.03 | ≤0.03 |
| Ciprofloxacin | ≤0.03 | ≤0.03 | ≤0.03 | 0.06–0.5 | 0.125 | 0.25 | |||
| Levofloxacin | ≤0.03–0.06 | ≤0.03 | 0.06 | 0.125–0.5 | 0.25 | 0.5 | |||
| Moxifloxacin | ≤0.03–0.25 | ≤0.03 | 0.06 | 0.125–2 | 0.25 | 0.5 | |||
| Morganella morganii | Mixed | 11 | Finafloxacin | 0.125–16 | 1 | 16 | 0.03–16 | 0.25 | 4 |
| Ciprofloxacin | ≤0.008–>16 | 0.008 | 4 | 0.016–>16 | 0.06 | >16 | |||
| Serratia marcescens | Susceptible | 12 | Finafloxacin | 0.125–8 | 1 | 8 | 0.06–4 | 0.25 | 2 |
| Ciprofloxacin | ≤0.03–1 | ≤0.03 | 1 | 0.125–>16 | 1 | 16 | |||
| Levofloxacin | ≤0.03–4 | 0.125 | 1 | 0.25–>16 | 1 | 16 | |||
| Moxifloxacin | 0.06–4 | 0.125 | 2 | 1–>16 | 4 | >16 | |||
| Stenotrophomonas maltophilia | Mixed | 19 | Finafloxacin | 0.5–32 | 2 | 4 | 0.125–16 | 0.5 | 1 |
| Ciprofloxacin | 0.5–64 | 4 | 8 | 2–256 | 8 | 64 | |||
| Pseudomonas aeruginosa | Susceptible | 22 | Finafloxacin | 1–32 | 4 | 16 | 0.25–8 | 0.5 | 2 |
| Ciprofloxacin | 0.03–1 | 0.25 | 0.5 | 0.125–2 | 0.5 | 1 | |||
| Resistant | 9 | Finafloxacin | >32 | NC | NC | 16–>32 | NC | NC | |
| Ciprofloxacin | 8–32 | NC | NC | 8–>32 | NC | NC | |||
| Haemophilus influenzae | Susceptible | 35 | Finafloxacin | ≤0.004–0.06 | 0.008 | 0.03 | ND | ND | ND |
| Ciprofloxacin | 0.008–0.03 | 0.008 | 0.016 | ND | ND | ND | |||
| Levofloxacin | 0.008–0.03 | 0.016 | 0.03 | ND | ND | ND | |||
| Moxifloxacin | ≤0.004–0.125 | 0.016 | 0.06 | ND | ND | ND | |||
| Neisseria gonorrhoeae | Mixed | 10 | Finafloxacin | ≤0.03–0.25 | 0.06 | 0.125 | ≤0.03–0.125 | 0.06 | 0.06 |
| Ciprofloxacin | ≤0.03–0.125 | 0.06 | 0.06 | ND | ND | ND | |||
| Levofloxacin | 0.06–0.25 | 0.06 | 0.25 | 0.06–0.125 | 0.06 | 0.125 | |||
| Moxifloxacin | ≤0.03–0.125 | 0.06 | 0.06 | ND | ND | ND | |||
a
According to the CLSI susceptibility breakpoint for ciprofloxacin (3). Mixed, susceptible and resistant.
b
ND; not determined (usually strains grew poorly at low pH); NC, MIC50 and MIC90 were not calculated for groups of less than 10 strains.