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. 2011 Sep;55(9):4012–4018. doi: 10.1128/AAC.00223-11

Table 3.

In vitro susceptibilities to three distinct CAPs, cell membrane fluidity, and cell wall thickness of 10 study strain pairsa

Strain % survival (mean ± SD) after 2 h of exposure to:
 Cell membrane fluidity (PI value) Cell wall thickness (nm)
tPMPs
 hNP-1
 PMB
0.5 μg/ml 0.25 μg/ml 10 μg/ml 5 μg/ml 40 μg/ml 20 μg/ml
CB1483 18 ± 12 32 ± 18 45 ± 11 59 ± 11 7 ± 8 31 ± 18 0.333 ± 0.012 35.9 ± 3.8
CB185 67 ± 22* 95 ± 10* 56 ± 8 69 ± 14 9 ± 11 38 ± 16 0.331 ± 0.004 38.8 ± 3.4**
CB5079 3 ± 4 22 ± 8 3 ± 6 21 ± 7 0 ± 0 40 ± 18 0.453 ± 0.042 30.7 ± 3.2
CB5080 48 ± 7* 74 ± 11* 40 ± 5* 60 ± 13* 37 ± 7* 65 ± 19 0.369 ± 0.047 39.3 ± 4.2***
CB5083 14 ± 7 32 ± 15 0 ± 0 0 ± 0 0 ± 0 33 ± 18 0.394 ± 0.064 30.6 ± 3.1
CB5082 78 ± 10* 83 ± 12* 33 ± 13* 48 ± 8* 52 ± 7* 77 ± 14* 0.325 ± 0.046 37.0 ± 4.1***
CB5088 3 ± 2 17 ± 8 9 ± 9 20 ± 13 5 ± 8 52 ± 10 0.388 ± 0.033 33.7 ± 3.3
CB5089 41 ± 3* 76 ± 17* 19 ± 9 40 ± 9 26 ± 7* 59 ± 3 0.343 ± 0.008 34.6 ± 2.6*
CB1631 22 ± 12 31 ± 24 15 ± 14 30 ± 24 6 ± 7 46 ± 25 0.375 ± 0.021 39.7 ± 3.5
CB1634 87 ± 8* 100 ± 12* 72 ± 16* 79 ± 10* 12 ± 9 56 ± 28 0.280 ± 0.045* 39.8 ± 3.5
CB1663 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 20 ± 5 0.422 ± 0.081 29.4 ± 3.0
CB1664 84 ± 36* 82 ± 39* 67 ± 17* 64 ± 14* 57 ± 21* 69 ± 5* 0.334 ± 0.075 44.7 ± 5.3*
CB5057 80 ± 10 80 ± 6 24 ± 6 34 ± 5 40 ± 24 85 ± 1 0.321 ± 0.022 34.2 ± 4.4
CB5059 94 ± 13 95 ± 19 70 ± 21* 76 ± 20* 69 ± 20 83 ± 13 0.265 ± 0.054 36.0 ± 3.6*
CB5062 69 ± 27 74 ± 35 23 ± 9 44 ± 8 0 ± 0 7 ± 12 0.332 ± 0.098 32.3 ± 3.0
CB5063 85 ± 2 96 ± 7 64 ± 33 69 ± 28 20 ± 21 56 ± 23* 0.331 ± 0.014 36.2 ± 4.0***
CB5015 80 ± 36 82 ± 28 65 ± 7 66 ± 3 44 ± 12 58 ± 1 0.375 ± 0.051 41.4 ± 6.7
CB5016 85 ± 32 92 ± 19 87 ± 8* 82 ± 3* 50 ± 10 48 ± 8 0.342 ± 0.035 43.1 ± 6.1b
CB5021 24 ± 11 57 ± 14 16 ± 12 28 ± 24 22 ± 13 66 ± 13 0.295 ± 0.020 30.4 ± 3.8
CB5020 101 ± 16* 111 ± 5* 83 ± 5* 73 ± 6* 82 ± 30* 95 ± 41 0.083 ± 0.04* 47.7 ± 7.5***
a

Pairs of isolates are represented by alternative shading and no shading, with the first strain in each pair being the DAPs parental strain and the second one in each pair being the DAPr strain. *, P < 0.05 versus parental strain; **, P = 0.05 versus parental strain; ***, P < 0.0001 versus parental strain.

b

P = 0.057 versus parental strain value.