Table 2.
Individual pharmacokinetic parametersa
| Patient | Oseltamivir |
Oseltamivir carboxylate |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg/liter) | Tmax (h) | AUC (μg · h/liter) | CL/F (liter/h) | V/F (liters) | t1/2 (h) | Cmax (μg/liter) | Tmax (h) | C24 (μg/liter) | AUC (μg · h/liter) | CL/F (liter/h) | V/F (liter) | t1/2 (h) | |
| 1 | 121 | 1.00 | 288 | 260 | 339 | 1.19 | 176 | 4 | 19.62 | 2,430 | 28.1 | 315 | 7.78 |
| 2 | 27.7 | 2.25 | 139 | 539 | 951 | 2.05 | 166 | 6 | 19.92 | 2,106 | 32.4 | 271 | 5.80 |
| 3 | 39.6 | 1 | 146 | 514 | 780 | 1.03 | 174 | 4 | 9.43 | 1,850 | 36.9 | 343 | 6.44 |
| 4 | 48.3 | 0.5 | 150 | 499 | 539 | 0.96 | 132 | 6 | 26.88 | 1,928 | 35.4 | 355 | 6.96 |
| 5 | 50.4 | 2.33 | 175 | 429 | 390 | 0.53 | 231 | 6 | 36.87 | 2,926 | 23.3 | 257 | 7.65 |
| 6 | 51.3 | 2 | 139 | 539 | 537 | 0.91 | 261 | 4 | 10.7 | 2,296 | 29.7 | 197 | 4.59 |
| Mean ± SD | 56.4 ± 32.9 | 1.51 ± 0.77 | 173 ± 58 | 461 ± 106 | 589 ± 234 | 1.22 ± 0.50 | 190 ± 47 | 5 ± 1 | 20.52 ± 10.34 | 2,256 ± 394 | 30.9 ± 5.0 | 290 ± 60 | 6.54 ± 1.21 |
a
Tmax, time to maximal plasma concentration; C24, concentration observed 24 h after the intake; V/F, apparent distribution volume.