Table 4.

Pharmacokinetic parameters of oseltamivir: present results and comparison with published data^a

Study or reference	CL/F		V/F		AUCb		t1/2 (h)
	Mean (liters/h)	Δ%	Mean (liters)	Δ%	Mean (μg-h/liter)	Δ%	Mean	Δ%
Present study	461 (9.07c)		589 (11.7d)		173		1.22
28	8.29c	+5	11.0d	+6	NA		1.01	+21
7	550	−16	1,720	−66	152	+14	2.21	−45
19	529	−13	NA		156	+12	2.2	−45
23	642	−28	NA		141	+23	2.30	−47
1	653	−29	1,350	−56	119	+46	1.45	−16
4	600e	−23	NA		125	+39	1.33	−8
22	735e	−37	NA		102	+71	1.91	−36
15	547e	−16	NA		137	+27	2.94	−58

^aNA, not available; V/F, apparent distribution volume; V/BW, weight-normalized distribution volume; AUC, area under the curve from time zero to infinity for single-dose studies or between two doses at steady state for repeated-dose studies; Δ%, relative change (in percent) compared to the results of the cited study.

^bNormalized for a 75-mg dose.

^cThe values are CL/BW (in liters/h/kg).

^dThe values are V/BW (in liters/kg).

^eDerived from AUC and dose.