Table 5.
Pharmacokinetic parameters of oseltamivir carboxylate: present results and comparison with published dataa
| Study or reference | CL/F |
V/F |
AUCb |
t1/2 |
||||
|---|---|---|---|---|---|---|---|---|
| Mean (liters/h) | Δ% | Mean (liters) | Δ% | Mean (μg · h/liter) | Δ% | Mean (h) | Δ% | |
| Present study | 30.9 (0.60c) | 290 (5.61d) | 2,256 | 6.54 | ||||
| 28 | 0.42c | +43 | 3.31d | +69 | NA | 5.08 | +28 | |
| 7 | 24.2 | +28 | 153 | +89 | 3,220 | −30 | 7.44 | −12 |
| 19 | 20.7 | +49 | NA | 3,450 | −35 | 6.0 | +9 | |
| 23 | 21.2 | +46 | NA | 3,310 | −32 | 6.60 | −1 | |
| 1 | 24.8 | +25 | 213 | +36 | 3,176 | −29 | 6.40 | +2 |
| 4 | 23.1 | +34 | NA | 2,950 | −24 | 6.56 | 0 | |
| 22 | 30.1 | +3 | NA | 2,270 | −1 | 9.67 | −32 | |
| 15 | 12.9 | +135 | NA | 5,290 | −57 | 7.0 | −6 | |
| 12 | 15.4 | +100 | NA | 4,875 | −54 | 8.60 | −24 | |
a
NA, not available; V/F, apparent distribution volume; V/BW, weight-normalized distribution volume; AUC, area under the curve from time zero to infinity for single-dose studies or between two doses at steady state for repeated-dose studies; Δ%, relative change (in percent) compared to the results of the cited study.
b
Normalized for a 75-mg dose.
c
The values are CL/BW (in liters/h/kg).
d
The values are V/BW (in liters/kg).