Fig. 2.

Replication capacity of replicons carrying different resistance mutations transfected in Huh-Lunet cells. Huh-Lunet cells were transiently transfected with the mutant replicons. RNA replication was measured by means of a luciferase assay for 4 days posttransfection. Data are normalized to the value at 4 h posttransfection to normalize for transfection efficiency. Values shown are expressed as a percentage of the wild-type value at the corresponding time point posttransfection. Data are mean values ± standard deviations for at least three independent experiments.