Table 1.
MIC and MBC or MFC values of B-Lock against microorganisms associated with catheter infections
| Isolatea | B-Lock MIC (% solution) |
B-Lock MBC or MFC (% solution)b |
||
|---|---|---|---|---|
| Range | 50%/90%c | Range | 50%/90%c | |
| Bacterial | ||||
| Acinetobacter baumanii | 0.8–12.5 | 6.25/12.5 | 12.5–>25 | >25/>25 |
| Coagulase-negative staphylococcus, methicillin resistant | 0.003125–25 | 1.6/25 | 0.25–>25 | >25/>25 |
| Coagulase-negative staphylococcus, methicillin susceptible | 0.00625–25 | 0.2/6.25 | 0.025–>25 | >25/>25 |
| Enterobacter sp. | 0.0125–25 | 0.4/25 | 0.1–>25 | >25/>25 |
| Enterococcus faecalis | 0.003125–25 | 0.0125/12.5 | 0.05–>25 | 0.8/>25 |
| Escherichia coli | 0.00625–25 | 0.4/25 | 0.0125–>25 | 12.5/>25 |
| Klebsiella pneumoniae | 0.0125–25 | 3.125/25 | 0.05–>25 | >25/>25 |
| Pseudomonas aeruginosa | 0.1–25 | 6.25 | 1.6–>25 | >25/>25 |
| Serratia marcescens | 0.1–12.5 | 0.2 | 1.6–>25 | >25/>25 |
| Staphylococcus aureus, methicillin resistant | 0.025–25 | 0.05 | 0.1–>25 | 0.4/>25 |
| Staphylococcus aureus, methicillin susceptible | 0.0125–12.5 | 0.025 | 0.05–>25 | 0.8/>25 |
| Fungal | ||||
| Candida albicans | 0.0002–0.003 | 0.0015/0.003 | 12.5–>50 | 50/50 |
| Candida glabrata | 0.0004–0.006 | 0.0015/0.003 | 25–>50 | 50/50 |
| Candida krusei | 0.0008–0.006 | 0.003/0.006 | 25–>50 | >50/>50 |
| Candida parapsilosis | 0.0012–0.025 | 0.006/0.012 | 50–>50 | 50/>50 |
| Candida tropicalis | 0.0004–0.05 | 0.006/0.025 | 25–>50 | 50/50 |
a
Throughout, n = 25, except for S. marcescens (n = 18).
b
Minimal bactericidal concentrations (MBC) are shown for bacterial isolates, and minimal fungicidal concentrations (MFC) are shown for fungal isolates.
c
50%/90%, MIC50/MIC90, MBC50/MBC90, or MFC50/MFC90.