. 2011 Sep;55(9):4050–4057. doi: 10.1128/AAC.00159-11

Table 1.

Noncompartmental analysis of oseltamivir (OS) and oseltamivir carboxylate (OC) pharmacokinetics^a

Regimen	Oseltamivir							Oseltamivir carboxylate
Regimen	t_½ (h)	k_el (h⁻¹)	C_max (ng/ml)	T_max (h)	AUC_0-∞ (ng/ml h)	AUC_0-12 (ng/ml h)	AUC_obs (ng/ml h)	t_½ (h)	k_el (h⁻¹)	C_max (ng/ml)	T_max (h)	AUC_0-∞ (ng/ml h)	AUC_0-12 (ng/ml h)	AUC_obs (ng/ml h)
B	2.321	0.3	206	0.5	387	373	377	6.291	0.11	825	4	10,215	7,041	9,023
	1.428	0.076	115	0.5	270	259	264	5.286	0.07	653	3	7,459	5,684	6,976
	9.08	0.485	345	1.25	527	498	498	9.865	0.131	1,260	4	14,720	10,625	13,609
C	3.664	0.19	216	0.5	409	379	396	6.456	0.107	825	3.5	9,904	6,794	8,793
	1.499	0.063	106	0.5	270	257	262	5.25	0.082	726	2	7,464	5,456	6,850
	10.944	0.462	433	3	560	480	525	8.413	0.132	1,140	6	14,686	10,046	13,296
D	2.565	0.275	235	0.5	413	395	400	6.175	0.112	831	3.9	10,080	6,857	9,002
	1.05	0.041	103	0.5	277	267	267	5.014	0.073	653	2	7,382	5,787	6,863
	16.842	0.66	452	3	734	513	513	9.491	0.138	1,170	4.5	14,886	10,372	13,612

Median values are given in the top line of each row, and underneath are the range values. Regimen B, 150 mg of oseltamivir administered p.o. q12h for 3 days; regimen C, the same as regimen B, with the addition of 50 mg/h zanamivir i.v. infusion for 72 h; regimen D, the same as regimen B, with the addition of zanamivir 600 mg i.v. q12h for 3 days. t_½, elimination half life; k_el, elimination rate constant; C_max, maximum concentration; T_max, time to maximum concentration; AUC_0-∞, area under the plasma concentration-time curve extrapolated to infinity; AUC_0-12, area under the plasma concentration-time curve between 0 and 12h; AUC_obs, area under the plasma concentration-time curve between time zero and the time of the last measured concentration.