Table 2.

Oseltamivir carboxylate pharmacokinetic parameters estimated from a one-compartment model^a

Regimenb	AUC0-∞ (ng/ml h)	Cmax (ng/ml)	Ka (h−1)	tlag (h)	kel (h−1)	t½ (h)	Tmax (h)	CL (liter/kg/h)	V (liter/kg)
B	7,072	587	0.606	0.434	0.129	5.384	3.737	0.329	2.495
	5,828	454	0.316	0.241	0.085	3.914	2.761	0.222	2.001
	10,816	856	1.198	1.607	0.177	8.138	5.581	0.472	3.956
C	6,871	603	0.65	0.535	0.129	5.356	4.066	0.335	2.549
	5,880	495	0.15	0.292	0.11	1.634	2.359	0.237	0.721
	10,140	767	2.514	2.496	0.424	6.322	5.572	0.468	3.816
D	6,901	629	0.582	0.41	0.148	4.695	3.59	0.341	2.35
	5,846	378	0.283	0.283	0.091	3.441	2.911	0.231	1.582
	10,416	871	0.865	1.335	0.201	7.654	5.496	0.471	4.52

^aMedian values are given in the top line of each row, and underneath are the range values.

^bRegimen B, 150 mg of oseltamivir administered p.o. q12h for 3 days; regimen C, the same as regimen B, with the addition of 50 mg/h zanamivir i.v. infusion for 72 h; regimen D, the same as regimen B, with the addition of zanamivir 600 mg i.v. q12h for 3 days. AUC_0-∞, total area under the plasma concentration time curve; C_max, maximum plasma concentration; T_max, time of maximum plasma concentration; K_a, absorption rate constant; t_lag, lag time; k_el, elimination rate constant; t_½, elimination half life; CL, clearance; V, apparent volume of distribution.