Table 5.

Zanamivir pharmacokinetics estimated from one- and two-compartment models using regimen A^a

Model	kel (h−1)	t1/2 (h)	V1 (liter/kg)	CL (liter/kg/h)	V2 (liter/kg)	CL2 (liter/kg/h)	AUC (ng/ml h)	Cmax (ng/ml)	tα1/2 (h)	tβ1/2 (h)
1 Compartment	0.537	1.291	0.222	0.114			108,584	6,833
	0.388	0.985	0.178	0.088			94,314	5,895
	0.704	1.787	0.252	0.16			145,017	9,048
2 Compartment	0.813	0.853	0.138	0.111	0.109	0.07	110,924	7,014	0.386	2.044
	0.602	0.568	0.078	0.085	0.069	0.025	97,191	6,061	0.139	1.607
	1.221	1.152	0.206	0.157	0.164	0.237	150,502	9,337	0.838	4.039

^aMedian values are given in the top line of each row, and underneath are the range values. Regimen A, 800 mg zanamivir infused during 16 h. k_el, elimination rate constant; t_1/2, elimination half life; V₁, volume of the central (or only) compartment; CL, clearance from the central (or only) compartment; V₂, volume of the second compartment; CL₂, intercompartmental clearance; AUC, total area under the concentration-time curve; C_max, maximum concentration; t_α1/2, half life corresponding to the initial elimination phase (in a two-compartment model); t_β1/2, terminal elimination half life.