Table 6.

Zanamivir pharmacokinetics estimated from one- and two-compartment models^a

Model	kel (h−1)	t1/2 (h)	V1 (liter/kg)	CL (liter/kg/h)	V2 (liter/kg)	CL2 (liter/kg/h)	AUC (ng/ml h)	Cmax (ng/ml)	tα1/2 (h)	tβ1/2 (h)
1 Compartment	0.832	0.834	0.17	0.149			63,705	48,317
	0.669	0.588	0.127	0.11			56,589	35,854
	1.179	1.037	0.2	0.198			92,939	57,596
2 Compartmentb	0.939		0.127	0.119	0.09	0.174	79,489	49,271	0.165	1.428
	0.613		0.06	0.085	0.052	0.053	67,307	36,624	0.04	0.957
	1.802		0.178	0.165	0.128	0.875	114,477	58,871	0.434	2.141

^aMedian values are given in the top line of each row, and underneath are the range values. Regimen D, 600 mg zanamivir infused during 30 min. k_el, elimination rate constant; t_1/2, elimination half life (in a one-compartment model); V₁, volume of the central (or only) compartment; CL, clearance from the central (or only) compartment; V₂, volume of the second compartment; CL₂, intercompartmental clearance; AUC, total area under the concentration-time curve; C_max, maximum concentration; t_α1/2, half life corresponding to the initial elimination phase (in a two-compartment model); t_β1/2, terminal elimination half life.

^bOne subject was excluded, since the fit of the two-compartment model was poor.