Table 1.

MIC/MBCs of NB-003 and comparators against P. acnes

Agent(s)	MIC/MBC (μg/ml)
	Without sebum (n = 16 isolates)			With 50% sebum (n = 16 isolates)
	90%	50%	Range	90%	50%	Range
NB-003	0.5/2	0.5/2	0.25–1/0.5–2	128/1,024	128/1,024	64–256/256–1,024
NB-003 gel	1/2	0.5/21	0.5–1/1–4	128/1,024	128/1,024	64–256/128–>1,024
Erythromycin	1,000/>1,000	4/>1,000	≤0.25–>1,000/62.5–>1,000	1,000/>1,000	4/1,000	≤0.25–>1,000/62.5–>1,000
Clindamycin	500/>1,000	4/1,000	≤0.125–500/125–>1,000	500/>1,000	1/100	≤0.125–500/62.5–>1,000
Tetracycline	31/1,000	0.5/250	≤0.063–31.3/31.3–1,000	31.3/1,000	0.5/250	≤0.063–31.3/31.3–1,000
Benzoyl peroxide	50/200	50/200	≤50–100/100–400	400/1,600	200/800	≤50–400/800–1,600
Salicylic acid	1,000/2,000	1,000/2,000	50–1,000/2,000–>2,000	1,000/2,000	1,000/2,000	500–1,000/2,000–>2,000
0.3% NB-003 gel + 0.5% BPO	0.5/4	0.5/4	0.5–1/2–4	128/256	128/128	128/128–256
0.3% NB-003 gel + 2% salicylic acid	0.5/2	0.5/2	0.25–1/0.5–2	128/256	128/128	128/128–256