Table 3.

Comparison of ritonavir pharmacokinetic parameters during coadministration with darunavir and atazanavir once daily

Parameter	Ritonavir-darunavir vs ritonavir-atazanavir (GMR [90% CI])a
AUC0–24 (ng · h/ml)	0.62 (0.38–0.45)
AUC0–72 (ng · h/ml)	0.64 (0.40–0.47)
Cmax (ng/ml)	0.54 (0.30–0.40)
C24h (ng/ml)	0.88 (0.62–0.93)
Half-life, 0–24 h	2.31 (1.91–2.79)
Half-life, 0–72 h	1.25 (1.16–1.36)

^aRitonavir was coadministered once daily at 100 mg with darunavir (800 mg) or atazanavir (300 mg).