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Functional grouping of p53-induced genes (open bars) compared with the same grouping of 100 randomly selected genes (solid bars). Significant differences (P < 0.02) are indicated by an asterisk. p53-induced genes were enriched for genes involved in apoptosis, growth arrest, the cytoskeleton, growth factors, and cell adhesion. Genes involved in cell metabolism were less abundant compared with a randomly selected gene pool.
