Table 2.
Different functional groups of p53-regulated genes
| Function
|
Gene definition
|
p53 regulation
|
Response
|
Response to 50 μm zinc
|
UVa
|
γa
|
|---|---|---|---|---|---|---|
| Apoptosis | Fas/APO-1 | activation | intermediate | − | 0 | 3 |
| KILLER/DR5 | activation | intermediate | + | 0 | 1 | |
| Oxidative stress | Homo sapiens Pig3 | activation | intermediate | − | 0 | 3 |
| cystathionine-β-synthase | activation | intermediate | − | 0 | 1 | |
| serum amyloid a protein precursor | activation | late | − | 0 | 1 | |
| neutrophil cytosolic factor 2 | activation | late | − | 0 | 0 | |
| H. sapiens Pig12 (PIG12) | activation | transient | − | 0 | 0 | |
| superoxide dismutase 3; extracellular | repression | early | + | 2 | 2 | |
| Cell cycle | p21/Waf1 | activation | early | + | 1 | 1 |
| GADD45 | activation | early | + | 2 | 2 | |
| regulator of G-protein signaling 2 G0S8 | activation | early | + | 1 | 0 | |
| negative growth regulator MyD118 | activation | intermediate | + | 0 | 1 | |
| 14-3-3ς protein | activation | late | + | 1 | 2 | |
| cyclin-dependent kinase 2 | repression | early | + | 0 | 0 | |
| retinoblastoma-binding protein (RbAp46) | repression | early | + | 0 | 1 | |
| prothymosin α | repression | late | + | 0 | 0 | |
| ESTs; similar to CYCLIN B2 | repression | late | − | 0 | 1 | |
| MAD2 mitotic feedback protein Madp2 | repression | late | + | 0 | 0 | |
| lamin B receptor | repression | late | + | 2 | 3 | |
| DNA replication | DNA primase polypeptide 1 | repression | late | + | 0 | 1 |
| topoisomerase (DNA) II α | repression | late | − | 0 | 1 | |
| DNA replication licensing factor | repression | late | − | 0 | 0 | |
| chromosomal protein HMG-17 | repression | late | + | 0 | 1 | |
| high-mobility group 2 (HMG2) | repression | late | − | 0 | 0 | |
| ECM | collagen; type II α1 | activation | early | − | 0 | 2 |
| collagen; type VI α1 | activation | intermediate | + | 0 | 2 | |
| Cell migration | macrophage stimulating protein (msp) | activation | intermediate | − | 0 | 0 |
| plasminogen activator inhibitor (PAI-1) | activation | intermediate | − | 0 | 1 | |
| Nuclear matrix | nuclear matrix protein NRP/B (NRPB) | activation | early | + | 0 | 0 |
| Cytoskeleton | actin; α2 | activation | intermediate | − | 0 | 0 |
| keratin 5 | activation | intermediate | − | 0 | 0 | |
| keratin 17 | activation | late | − | 0 | 1 | |
| keratin 19 | activation | late | − | 1 | 1 | |
| Membrane protein | caveolin | activation | early | − | 0 | 0 |
| ANNEXIN XIII | activation | late | + | 1 | 2 | |
| Signal transduction | tyrosine-protein kinase receptor eck | activation | intermediate | − | 0 | 2 |
| Ral GDP dissociation stimulator | activation | intermediate | + | 0 | 0 | |
| interleukin-2 receptor β chain (IL-2Rb) | activation | late | + | 0 | 3 | |
| human DNA for rhoHP1, | activation | late | + | 0 | 1 | |
| HUMAN P2XM | activation | transient | + | 0 | 1 | |
| p21cdc42Hs kinase(ack) | activation | transient | + | 0 | 0 | |
| possible GTP-binding protein hsr1 | repression | early | + | 0 | 1 | |
| effector cell protease receptor-1 (EPR-1) | repression | late | − | 2 | 0 | |
| ADP-ribosylation factor-I (ARL2) | repression | late | + | 0 | 2 | |
| Myb proto-oncogene protein | repression | late | − | 1 | 0 | |
| ribosomal protein S6 kinase 2,90 KD | repression | transient | − | 1 | 0 | |
| InsP3 5-phosphatase | repression | transient | − | 0 | 0 | |
| CCAAT/enhancer binding prot. (C/EBPα) | repression | transient | − | 1 | 2 | |
| Growth factor | TGF-β superfamily protein | activation | early | + | 2 | 3 |
| inhibitor | IGFBP-3 | activation | late | + | 0 | 1 |
| transforming growth factor; α | activation | late | − | 0 | 3 | |
| BMP4 | activation | transient | + | 0 | 1 | |
| Angiogenesis | endothelin 2 | activation | intermediate | − | 0 | 3 |
| thrombospondin 1 | activation | transient | − | 0 | 0 |
a
Number of treated cell lines showed 2.5-fold or higher changes compared to control.