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. 2011 Sep;79(9):3596–3606. doi: 10.1128/IAI.00077-11

Fig. 6.

Fig. 6.

Pgd− and Pgd− Oat− L. monocytogenes strains activate the AIM2 inflammasome. (A) Pam3CSK4-stimulated immortalized shRNA AIM2 knockdown or shRNA scrambled macrophages were infected at an MOI of 5, and LDH was measured at 6 h. (B) IL-1β secretion was measured by ELISA in Pam3CSK4-stimulated immortalized shRNA AIM2 knockdown or shRNA scrambled immortalized macrophages (iBMM) infected for 6 h. Error bars represent standard deviations of the means determined in triplicate. Statistical significance was evaluated using Student's t test. Data are representative of more than 3 independent experiments with similar results. **, P < 0.0001. Lp fla, Legionella flagellin.