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. 2011 Sep;79(9):3821–3832. doi: 10.1128/IAI.05204-11

Fig. 1.

Fig. 1.

IDO gene expression is increased in M. avium subsp. paratuberculosis (MAP)-infected monocytes. Expression of IDO (A) and IL-12 (B) by the human monocytic cell line THP-1, infected at a 10:1 multiplicity of infection with M. avium subsp. paratuberculosis. Gene expression was assessed by qPCR at early time points postinfection. Replicates were carried out for control uninfected (n = 2 to 4) and M. avium subsp. paratuberculosis-infected (n = 4) cultures, harvested at 0, 4, 8, 24, and 48 h postinfection. *, P < 0.05; **, P < 0.0001 (compared to control cultures at the respective time point).