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MPLA treatment improves the host response to systemic infection caused by CLP. Mice were treated with MPLA by either intraperitoneal (A) or intravenous (B) routes prior to CLP. The rectal temperature was measured at 24 h, and survival was monitored out to 2 weeks after CLP. (C) Bacterial counts in peritoneal lavage fluid and blood were measured at 16 h after CLP. *, P < 0.05 compared to vehicle (n = 6 to 10 mice per group).
