Fig. 2.

MPLA treatment improves the host response to P. aeruginosa burn wound infection. Mice underwent a cutaneous burn followed by intraperitoneal treatment with MPLA or vehicle on days 3 and 4 postburn. The wounds were then infected with P. aeruginosa on day 5 postburn. (A) Survival was determined out to 2 weeks after burn wound infection, but no mice died beyond 7 days after wound infection. (B) Bacterial counts at the site of wound inoculation (area 3) and at locations distant from the inoculation site (areas 1 and 2) were determined 3 days after wound infection. (C) Total bacterial counts within the entire burn wound and in the lungs were determined 3 days after burn wound infection. *, P < 0.05 compared to vehicle (n = 6 to 10 mice per group).