Table 5.
Clinical presentation of Alaska Native and non-Native persons infected with Helicobacter pylori strains with and without the cagA gene and with vacA genotypes s1m1, s1m2, and s2m2 in Alaska from 1998 to 2005
| Clinical presentation |
cagA statusa |
vacA genotypeb |
|||||
|---|---|---|---|---|---|---|---|
| No. (%) of patients |
P value | No. (%) of patients with genotype |
P valuec | ||||
| Positive (n = 222) | Negative (n = 38) | s1m1 (n = 107) | s1m2 (n = 37) | s2m2 (n = 98) | |||
| Endoscopic evaluation | |||||||
| Duodenitis | 40 (18) | 6 (16) | 0.74 | 22 (21) | 9 (24) | 15 (15) | 0.42 |
| Esophagitis | 46 (21) | 17 (45) | 0.003 | 15 (14) | 11 (30) | 35 (36) | 0.001d |
| Moderate or severe gastritis | 96 (43) | 19 (50) | 0.44 | 48 (45) | 19 (51) | 44 (45) | 0.77 |
| All ulcers | 20 (9) | 3 (8) | 0.82 | 12 (11) | 3 (8) | 7 (7) | 0.58 |
| Gastric ulcer | 16 (7) | 2 (5) | 0.65 | 12 (11) | 1 (3) | 4 (4) | 0.07 |
| Medical chart review | |||||||
| History of gastritis | 93 (42) | 13 (34) | 0.37 | 46 (43) | 11 (30) | 43 (44) | 0.28 |
| History of PUD | 32 (14) | 4 (11) | 0.51 | 21 (20) | 4 (11) | 9 (9) | 0.08 |
| Ulcer at enrollment or history of PUD | 46 (21) | 6 (16) | 0.47 | 29 (27) | 4 (11) | 12 (12) | 0.01e |
a
Persons with both cagA-positive and cagA-negative H. pylori colonies were considered to be infected with a cagA-positive strain.
b
vacA genotype s2m1 was left out due to the small sample size (n = 1).
c
The P value examines differences in clinical outcomes among the 3 vacA genotypes. Boldface type indicates significance.
d
P value for s1m1 compared to the other 2 genotypes, 0.0003.
e
P value for s1m1 compared to the other 2 genotypes, 0.003.