Figure 1.

 Amino acid sequence of Pag and its murine and rat homologs. The sequence of human Pag (Prosperi et al. 1993) is given according to the single letter amino acid code. Letters above denote substitutions present in the murine homolog MSP23 (Ishii et al. 1993); letters below indicate substitutions in the rat homolog (HBP23) (Iwahara et al. 1995). Domains I and II are regions containing cysteine residues that are conserved among the family of peroxide reductases (Chae et al. 1994a). The arrows indicate the locations of the point of fusion of the two cDNAs recovered in the yeast two-hybrid screen with the B42 transactivation domain.