Figure 6.

Immunofluorescent localization of COR1 and RAD51 on meiotic chromosomes from Msh4^+/+ and Msh4^−/− females. The SC protein COR1 and the RecA homolog RAD51 were immunolocalized on chromosome spreads from oocytes at E19. COR1 immunofluorescence is shown in white, and RAD51 foci are localized in green. (A,B) chromosome spreads from wild-type oocytes at early zygonema (A, lower nucleus), late zygonema (B) and pachynema (A, top nucleus). (C,D) chromosome spreads from Msh4^−/− oocytes at zygonema, showing at least partial synapsis of chromosomes (C,D, arrows) and the coincident loss of RAD51 colocalization.