Fig. 11.

Increased lung cancer risk in Aα mutant mice. E64D/+;dnp53 and Δ5-6/+ mice were crossed to obtain the eight genotypes indicated. dnp53 is a dominant-negative fragment of p53. All mice received BP at 5 weeks of age. Mice without dnp53 were harvested 10 months later (black columns), and mice with dnp53 were harvested 6 months after BP application (grey columns). The table on the bottom shows the total number of mice, the number of mice with tumors, lung tumor incidences, and the average numbers of tumors (Tu) per tumor-bearing mouse. The higher tumor numbers in Δ/D (2.5) and Δ/D;dnp53 (2.8) have P values of 0.05 and 0.01, respectively, compared to the wild type. The P values above columns 2 to 4 are for the incidences in the mutant mice compared to the wild-type mice. D, E64D; Δ, Δ5-6. Note that neither tumor numbers nor sizes were comparable between mice with and without dnp53, since they were harvested at different times.