Fig. 8.

Susceptibility of Stc2^−/− MEFs to oxidative stress is rescued by inhibition of SOCE. (A) WT and Stim1^−/− Stim2^−/− (Stim dKO) MEFs were treated with H₂O₂ (200 μM) for 16 h, and cell survival was quantified relative to that of untreated controls using a colorimetric WST-8 assay. **, P < 0.01 by Student's t test. (B) Cell survival of WT and Stc2^−/− MEFs was quantified following treatment with H₂O₂ (200 μM) for 16 h in the presence or absence of 100 μM 2-APB. Data represent the means ± SEM from three experiments, each performed in triplicate. ***, P < 0.001 by one-way ANOVA; n.s., not significant.