Fig. 3.

Infection and suppression of subcutaneous sarcoma xenografts by intravenous VSV-rp30a. (A to C) SCID mice with subcutaneous human fibrosarcoma HT1080 xenografts were infected via tail vein with a single dose of 5.0E7 PFU of VSV-rp30a. Histological images of a representative tumor 7 dpi are shown: phase contrast showing two lobules of the tumor outlined in red (A), green fluorescence (C), and image overlay (B). (X and Y) High-magnification green fluorescence micrographs of two regions of the tumor indicated by white squares in C. (D) SCID mice with subcutaneous (s.c.) A673 xenografts were left uninfected (dotted line) or injected intravenously (i.v.) with a single dose of 5.0E7 PFU of VSV-rp30a (solid line) on day zero. Data points represent the mean volume, relative to day zero, for tumors under each condition. Error bars, SEM.