Fig. 1.

Sequence of SIVsmE660 Gag p27^CA known to affect TRIM5-mediated restriction. Partial sequences of the core nucleocapsid protein amino acids 72 to 101 of the two stocks of SIVsmE660 analyzed in this study are aligned against that of the closely related molecular clone SIVsmE543-3. The putative amino acids affecting restriction mediated by TRIM5^TFP (⁷⁴LPA⁷⁶) and TRIM5^CypA (R⁸³) are highlighted in red. Nonsynonymous variations from the SIVsmE543-3 sequence are color coded by frequency. X indicates a mixed amino acid sequence.