Fig. 2.
Acquisition of SIVsmE660 infection after repeated limiting-dose challenge is affected by TRIM5 genotype. (A) Kaplan-Meier curve analysis of the effects different TRIM5 genotypes have on the rate of acquisition of SIVsmE660 infection after repeated limiting-dose intrarectal challenge. The statistical significance of the rates of infection of the different TRIM5 genotypes was determined by log rank test. (B) A comparison of the numbers of challenges needed to productively infect animals expressing the different TRIM5 genotypes with SIVsmE660. Significance between the rates of infection of animals having the TRIM5TFP/CypA genotype and the other TRIM5 genotypes was determined by parametric generalized gamma model.