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(A) Surface model of the JRCSF gp120 core showing mutants resulting in decreased binding (blue) or increased binding (red). The gp120 domains that contain mutations most affecting affinities for VRC01 are denoted in circles of the following colors: green, loop D; gold, V5/β24; purple, CD4 BLP (CD4 binding loop); and blue, β24-α5 connection. (B) Histograms showing the number of mutant residues affecting virus neutralization or gp120 binding for VRC01, b12, and CD4-Ig.
