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. 1998 Mar 1;12(5):734–744. doi: 10.1101/gad.12.5.734

Figure 6.

Figure 6

 CycE is necessary, but not sufficient, for amplification. (A) BrdU foci in wild-type stage 12 nuclei. (B) Stage 12 chamber from a c323GAL4; UAS:Dap female showing that misexpression of the CycE inhibitor, Dacapo, drastically reduces BrdU labeling. (C) Overexpression of CycE in stage 10A. High magnification shows robust late replication corresponding to heterochromatic chromocenter but no BrdU incorporation characteristic of amplification. (D) DAPI image of C to show correspondence of labeling with DAPI bright chromocenter (cf. arrowheads in C and D). Scale bar, 10 μm.