Fig. 3.

Comparison of clusters obtained in our results with data from an experimental study of antibodies isolated from a single individual (24). In each case, panel i shows clusters that we obtained from a transition in the predominant wild-type strain compared to those residues identified in an experimentally defined chimeric approach (ii), some of which are known to disrupt the binding of an antibody that became ineffective at that point in time. (A) Transition of A/England/42/1972 to A/Port Chalmers/1/1973; (B) transition of A/Beijing/32/1992 to A/Wuhan/359/1995 (Bii shows the midregion only); (C) transition of A/Fujian/411/2002 to A/Wellington/1/2004. Substitutions are in blue, and the receptor binding site is in yellow.