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. 2011 Sep;85(17):8582–8596. doi: 10.1128/JVI.00652-11

Table 2.

Replication of parental and chimeric viruses in the brains of 1-day-old chicks

Virus Virus titer (log10 TCID50/g of brain)a
Intracerebral infection
Intranasal infection
2 dpi 3 dpi 3 dpi 4 dpi
rNDV 6.12 5.83 5.21 5.8
rAPMV-2 N.D.b N.D. N.D. N.D.
rNDV/2-F-HN N.D. N.D. N.D. N.D.
rAPMV-2/NDV-F-HN 2.65 3.86 3.30 3.61
rAPMV-2/NDV-F N.D. 1.81 1.86 1.92
a

One-day-old chicks in groups of 10 were infected with the indicated parental or chimeric virus (1 × 105 TCID50/bird) via the intracerebal or intranasal route, and two chicks per group were harvested on days 1 to 5 for virus titration. Brain tissue was collected and homogenized, and virus titers were determined by limiting dilution on DF1 cells with immunostaining using antibodies against the respective N protein.

b

N.D., not detected.