Fig. 5.

rVIG protects mice from lethal challenge with WRvFire and IHD-J-Luc in a dose-dependent manner. BALB/c mice were inoculated with rVIG at 3 μg/animal (squares), 30 μg/animal (triangles), or 100 μg/animal (inverted triangles) or with PBS (closed circles) and 2 days later challenged with WRvFire (A) or IHD-J-Luc (B). Mice were observed for lethality for 21 days; weight measurements were performed daily for 10 days and used to calculate mean percentages of initial weight ± SD (C and D). For the PBS-treated and WRvFire-challenged groups, n = 15. For all rVIG-treated groups infected with WRvFire, n = 12. For the PBS-treated and for rVIG (30 μg)-treated and IHDJ-Luc-challenged groups, n = 12. For the 3-μg and 100-μg rVIG-treated IHDJ-Luc-infected groups, n = 11. Results are representative of three experiments.