Table 5.
Synergy between GRFT and PRO140 for neutralization of HIV-1
| HIV-1 envelope pseudovirus | Single |
Combined |
CIa |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GRFT |
PRO140 |
GRFT |
PRO140 |
IC50 | IC80 | |||||
| IC50 (nM) | IC80 (nM) | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 | |||
| PVO.4 | 0.1 | 0.1 | 9.4 | 33.5 | 0.1 | 0.1 | 2.3 | 5.1 | 1.2 | 1.2 |
| QH0692.42 | 0.1 | 0.3 | 79.2 | 263.9 | 0.1 | 0.2 | 6.3 | 19.3 | 1.1 | 0.7 |
| COT6.15 | 0.8 | 2.6 | 21.2 | 128.6 | 0.3 | 0.6 | 13.1 | 46.4 | 1.0 | 0.6 |
| Du151.2 | 1.5 | 2.3 | 16.0 | 41.5 | 0.3 | 0.6 | 13.4 | 30.5 | 1.0 | 1.0 |
| CAP239.G3J | 0.2 | 0.9 | 36.2 | 165.8 | 0.2 | 0.4 | 6.5 | 22.1 | 1.2 | 0.6 |
| COT9.6 | 2.7 | 6.3 | 31.0 | 147.2 | 0.5 | 1.6 | 23.8 | 53.0 | 1.0 | 0.6 |
a
A CI of 0.3 to 0.7 indicates synergism, 0.7 to 0.85 indicates moderate synergism, 0.85 to 0.9 indicates slight synergism, and 0.9 to 1.1 indicates an additive effect. Cases where synergism occurred are in boldface.