Table 1.
Top nine biological categories determined by Ingenuity Pathways Analysisa
| Biological category | P value |
|---|---|
| Cellular movement | 3.76 × 10−21 to 3.41 × 10−5 |
| Cell-to-cell signaling and interaction | 1.08 × 10−18 to 4.44 × 10−5 |
| Tissue development | 1.08 × 10−18 to 2.55 × 10−5 |
| Immune cell trafficking | 7.17 × 10−16 to 4.44 × 10−5 |
| Connective tissue disorders | 2.07 × 10−15 to 1.89 × 10−5 |
| Inflammatory response | 3.27 × 10−15 to 4.62 × 10−5 |
| Hematological system development and function | 4.01 × 10−15 to 4.44 × 10−5 |
| Inflammatory disease | 2.38 × 10−14 to 2.12 × 10−5 |
| Skeletal and muscular disorders | 1.73 × 10−13 to 1.89 × 10−5 |
a
Categories were determined using Ingenuity Pathways Analysis of genes that were differentially expressed (ANOVA with corrected false discovery rate of 0.01) for each condition relative to results for mock-infected control mice (fold change, ≥2). Fisher's exact test correction P value was used to rank the significance associated for each category.