Figure 6.

 DNA binding by p95 and substrate elongation by purified telomerase show a similar length dependence. (A) Radiolabeled d(G₄T₂)₃ was used at a concentration of 20 nm with 100 nm p95. Assays contained single-stranded competitor DNA (Random-18) as well as double-stranded poly[d(I–C)]. In lanes 3–23, the indicated single-stranded competitors were added at 5-, 50-, and 500-fold that of the probe concentration. (B) Telomerase activity assays were performed with purified telomerase with the indicated single-stranded DNA primers at a concentration of 600 nm.