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TEM picture of a cultured megakaryocyte grown for 7 days from CD34+ CD38+ progenitors in the presence of Mpl-1, presenting signs of platelet formation. Protoplatelet-like peripheral sheet of cytoplasm has unfolded from the cell core. Specialized microtubule bundle running straight through the sheet of cytoplasm is not seen. Constriction zones are regularly disposed along this cytoplasmic extension (arrows). (Reproduced from Cramer et al.49) Fig. 3b, with permission from the publisher)
