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. 2011 Aug 15;25(16):1680–1685. doi: 10.1101/gad.16875711

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Copyright © 2011 by Cold Spring Harbor Laboratory Press

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Figure 1. — Neurog3^Cre-mediated exogenous Pdx1 expression. (A) Schematic presentation of CAG-CAT-Pdx1 and R26R^EYFP and Cre recombination. Exogenous Flag-tagged Pdx1 (Flag-Pdx1) and EYFP expression is activated after CAT or STOP cassette excision. (B–E) ^FlagPdx1 was only detected in the Neurog3^Cre-Pdx1^OE pancreas. No Gcg was detected in adult Neurog3^Cre-Pdx1^OE. (F,G) Increased Pdx1⁺ cells were detected in E14.5 Neurog3^Cre-Pdx1^OE compared with control. (H,I) Ectopic Pdx1 in Gcg⁺ cells in Neurog3^Cre-Pdx1^OE but not control (dashed lines in insets; white, Pdx1).