Figure 2.

Transient p53 restoration in the absence of MdmX is well tolerated. (A) Kaplan-Meier curve showing survival of mice of the indicated genotypes given daily injections of vehicle or tamoxifen for 1 wk. Controls are p53^KI/− mice treated with vehicle (n = 8), p53^KI/− treated with tamoxifen (n = 8), mdm2^−/−;p53^KI/− mice treated with vehicle (n = 6), mdmX^−/−;p53^KI/− mice treated with vehicle (n = 13), and mdmX^−/−;p53^−/− mice treated with tamoxifen (n = 4). (B) Mice of the indicated genotypes were treated daily with either vehicle or tamoxifen for 7 d. The left panels show H&E staining of bone marrow, spleen, and thymus. The right panels show BrdU staining of the same organs (BrdU was administered 2 h prior to sacrifice). (C) H&E, TUNEL, and BrdU staining of sections of small intestine from mice treated as in B.