Figure 3.

Permanent p53 restoration is lethal in the absence of MdmX. (A) Kaplan-Meier curve showing survival of mice of the indicated genotypes given continuous daily injections of vehicle or tamoxifen. Controls are mdmX^+/+;p53^KI/− mice treated with tamoxifen (n = 13), mdmX^−/−;p53^KI/− mice treated with vehicle (n = 9), and mdmX^−/−;p53^−/− mice treated with tamoxifen (n = 6). (B) H&E staining of organs harvested from mdmX^+/+;p53^KI/− and mdmX^−/−;p53^KI/− mice treated continuously with daily tamoxifen for 26 d. (C) H&E, TUNEL, and Ki67 staining of small intestine harvested from mdmX^+/+;p53^KI/− and mdmX^−/−;p53^KI/− mice treated continuously with daily tamoxifen for 26 d.