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The pathological effects of transient p53 restoration in the absence of MdmX are reversible. (A) Mice of the indicated genotypes were treated daily with tamoxifen for 7 d and sacrificed 7 d after. The left panels show BrdU staining of sections of bone marrow, spleen, and thymus (BrdU was administered 2 h prior to sacrifice). The right panels show H&E staining of the same organs. (B) H&E, TUNEL, and BrdU staining of small intestine sections from mice treated as in A.
