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Stem/progenitor cells can recover from p53 restoration in the absence of MdmX. Hematopoietic stem/progenitor cells (Lin−, Sca1+, CD150+, and CD48−) were quantified in mice of the indicated genotypes, treated with tamoxifen as indicated. The last two columns show counts from mdmX−/−;p53KI/− mice 7 d and 14 d after a 7-d tamoxifen treatment, respectively. (*) P < 0.05; (**) P < 0.01; (n.s.) not significant.
