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Restoration of p53 in the absence of MdmX extends overall survival in lymphoma-bearing mice. mdmX+/+;p53KI/−;EμMyc and mdmX−/−;p53KI/−;EμMyc tumors (the graph legend indicates the mdmX genotype only) were transplanted into wild-type recipients. Ten days after transplant, recipient mice were treated with either vehicle or tamoxifen for 1 wk. Their survival is plotted as a Kaplan-Meier curve.
