Table 4.
Bone cancer in vitro and ex vivo studies
| Murine cell line\tissue | Tumour induction (cell line) | Expressing | Apoptosis | Bone loss | Reference |
|---|---|---|---|---|---|
| NCTC-2472 | NA | CB1, CB2 | WIN-2 | – | Hald et al., 2008 |
| Femur | NCTC-2472 | – | – | No Δ by WIN-2 | Hald et al., 2008 |
| DRG | NCTC-2472 | ↑ by CB2 ipsi; no Δ CB1 | – | – | Hald et al., 2008 |
| Spinal cord | NCTC-2472 | No Δ CB1, CB2 | – | – | Hald et al., 2008 |
| DRG | NCTC-2472 | ↑ by CB1 ipsi | – | – | Khasabova et al., 2008 |
| DRG and plantar skin | NCTC-2472 | ↑ by FAAH activity | – | – | Khasabova et al., 2008 |
| Spinal cord | NCTC-2472 | No Δ CB1 | – | – | Furuse et al., 2009 |
| Spinal cord and DRG | NCTC-2472 | No Δ CB2 | – | – | Curto-Reyes et al., 2010 |
| Spinal cord and DRG | B16-F10 | No Δ CB2 | – | – | Curto-Reyes et al., 2010 |
| Femur | NCTC-2472 | – | – | ↓ by AM1241 | Lozano-Ondoua et al., 2010 |
↑, increase; ↓, decrease; –, not tested; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; DRG, dorsal root ganglion; FAAH, fatty-acid amide hydrolase; ipsi, ipsilateral side; no Δ, no change; NA, not applicable; WIN-2, WIN55,212-2.