Figure 4.

Sequence of the son-1 gene. (A) son-1 cDNA sequence and deduced amino acid sequence. The boxed sequence is derived from alternative splicing at the end of exon 1, which leads to additional two amino acids as indicated in parentheses. This alternative splicing does not change the overall protein structure. (Shaded regions) HMG boxes; (***) stop codon; (arrows) molecular lesion of the sy549 allele. (B) Comparison of the HMG box A and box B sequences between SON-1 and HMG1-like proteins of Drosophila melanogaster, Mus musculus, and Homo sapiens. Consensus resides between SON-1 and other HMG1-like proteins are shaded. (*) Unusual valine residue found in the HMG box A of SON-1 protein.