Figure 8.

Model for SON-1 function. SON-1 and a POP-1-like protein antagonistically regulate gene expression in Wnt-responding cells. The POP-1-like activity inhibits gene transcription, whereas SON-1 facilitates gene transcription. SON-1 might facilitate gene transcription after the inhibitory effect of the POP-1-like activity is relieved on activation of the Wnt pathway. SON-1 could change the chromatin conformation in favor of gene expression. Alternatively, SON-1 could interact with other transcription factors to help stimulate gene expression. (POP-1) A POP-1-like protein; (TF) transcription factor.