Skip to main content
. 2011 Aug;163(7):1533–1549. doi: 10.1111/j.1476-5381.2011.01444.x

Figure 5.

Figure 5

MAGL inhibitor JZL184 attenuates COX-2 elevation-induced enhancement of mEPSCs. Hippocampal neurons in culture treated with IL-1β or LPS were the same as described in Figure 2. (A1) Representative sweeps of mEPSCs recorded in vehicle control-, LPS-, LPS+JZL184 (1 µM)- and LPS+JZL184+GW9662 (5 µM)-treated neurons. Scale bar: 20 pA/2 s. (A2) Mean percentage changes in the frequency of mEPSCs in neurons with different treatments. (A3). Mean percentage changes in the amplitude of mEPSCs. (B1) Representative sweeps of mEPSCs recorded in vehicle control-, IL-1β-, IL-1β+ JZL184 (1 µM)- and IL-1β+ JZL184+GW9662 (5 µM)-treated neurons. (B2) Mean percentage changes in the frequency of mEPSCs. (B3) Mean percentage changes in the amplitude of mEPSCs. **P < 0.01 compared with the vehicle control; ##P < 0.01 compared with IL-1β or LPS; §§P < 0.01 compared with IL-1β+ JZL184 or LPS+JZL184 (n = 23–30).