Table A1. Summary of aggregated data of clustered outbreak strains, sequences, and properties of the outbreaks within such clusters for each of the genotypes, 1999–2008.*.
| GT | Total no. strains | No. (%) strains in clusters | No. (%) strains not in clusters | Minimum similarity within GT, % | Total no. clusters | Cluster size, range† | Cluster size, median† | No. (%) FB outbreak strains | No. sign possible FB clusters | No. (%) FHB outbreak strains | No. sign FHB clusters | No. (%) PB outbreak strains | No. sign PB clusters | No. (%) UN outbreak strains | No. sign UN clusters |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I.1 | 24 | 19 (79) | 5 (21) | 91.2 | 4 | 2–7 | 5 | 8 (33)‡ | 1¶ | 0 | 0 | 2 (8) | 0 | 14 (58) | 0 |
| I.2 | 34 | 20 (59) | 14 (41) | 97.5 | 5 | 2–6 | 5 | 5 (15) | 1¶ | 0 | 0 | 0 | 0 | 29 (85)§ | 0 |
| I.3 | 43 | 16 (37) | 27 (63) | 78.3 | 5 | 2–6 | 4 | 6 (14) | 1¶ | 0 | 0 | 2 (5) | 0 | 35 (81) | 0 |
| I.4 | 40 | 23 (58) | 17 (42) | 94.8 | 8 | 2–5 | 2 | 8 (20)‡ | 1¶ | 2 (5)‡ | 1¶ | 0 | 0 | 30 (75) | 0 |
| I.5 | 6 | 5 (83) | 1 (17) | 93.1 | 2 | 2–3 | 2.5 | 2 (33)§ | 0 | 0 | 0 | 0 | 0 | 4 (67) | 0 |
| I.6 | 20 | 13 (65) | 7 (35) | 88.7 | 4 | 2–5 | 3 | 4 (20)§ | 1# | 1 (5)§ | 0 | 2 (10) | 0 | 13 (65) | 0 |
| II.1** | 28 | 10 (36) | 18 (64) | 90.9 | 4 | 2–3 | 2.5 | 6 (21)‡ | 0 | 0 | 0 | 12 (43)‡ | 0 | 10 (36) | 0 |
| II.2 | 30 | 9 (29) | 21 (71) | 82.4 | 4 | 2–3 | 2 | 11 (37)‡ | 0 | 0 | 0 | 3 (10) | 0 | 16 (53) | 0 |
| II.3** | 136 | 70 (52) | 66 (48) | 90.5 | 14 | 2–15 | 3 | 15 (11) | 0 | 0 | 0 | 35 (26)‡ | 4¶# | 86 (63) | 0 |
| II.4** | 950 | 691 (73) | 254 (27) | 82.4 | 47 | 2–361 | 3 | 41 (4) | 3¶# | 2†† | 0 | 178 (19)§ | 3¶# | 729 (77)‡ | 4¶# |
| II.5 | 3 | 2 (66) | 1 (33) | 97.0 | 1 | 2 | 2 | 1 (33) | 0 | 0 | 0 | 0 (0) | 0 | 2 (67) | 0 |
| II.6** | 54 | 30 (56) | 24 (44) | 92.0 | 8 | 2–15 | 2 | 11 (20)‡ | 1¶ | 1 (2) | 0 | 6 (11) | 1¶ | 36 (67) | 0 |
| II.7 | 57 | 39 (68) | 18 (32) | 96.2 | 4 | 2–28 | 3 | 13 (23)‡ | 1# | 0 | 0 | 6 (11) | 1¶ | 38 (67) | 0 |
| II.8 | 4 | 2 (50) | 2 (50) | 96.0 | 1 | 2 | 2 | 2 (50)‡ | 0 | 0 | 0 | 0 (0) | 0 | 2 (50) | 0 |
| II.10 | 3 | 0 | 3 (100) | 97.0 | 0 | NA | NA | 0 | 0 | 0 | 0 | 2 (67)§ | 0 | 1 (33) | 0 |
| II.11 | 1 | 0 | 1 (100) | NA | 0 | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 1 (100) | 0 |
| II.12 | 4 | 0 | 4 (100) | 93.9 | 0 | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 4 (100) | 0 |
| II.13 | 3 | 0 | 3 (100) | 96.6 | 0 | NA | NA | 1 (33) | 0 | 0 | 0 | 0 | 0 | 2 (67) | 0 |
| II.14 | 3 | 0 | 3 (100) | 99.5 | 0 | NA | NA | 1 (33) | 0 | 0 | 0 | 0 | 0 | 2 (67) | 0 |
| II.16 | 4 | 0 | 4 (100) | 97.5 | 0 | NA | NA | 0 | 0 | 0 | 0 | 1 (25) | 0 | 3 (75) | 0 |
| II.17 | 1 | 0 | 1 (100) | NA | 0 | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 1 (100) | 0 |
| II.NA1 | 6 | 2 (50) | 4 (50) | 94.2 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 2 (50) | 0 | 2 (50) | 0 |
| II.NA3 |
1 |
0 |
1 (100) |
NA |
0 |
NA |
NA |
0 |
0 |
0 |
0 |
0 |
0 |
1 (100) |
0 |
| Overall | 1456 | 938 (64) | 518 (36) | 112 | 2–364 | 136 (9) | 10 | 6†† | 1 | 252 (17) | 9 | 1062 (73) | 4 |
*GT, genotype; FB, foodborne; FHB, food-handler borne; PB, person-borne; UN, unknown; NA, not applicable. †Size of a strain cluster is the number of outbreak-representative strains within a molecular cluster of outbreaks, i.e., 2–7 outbreaks (not 2–7 patients per outbreak) ‡Genotypes with significantly higher proportion (p<0.05) of outbreaks with this transmission mode, when compared to the proportion in the total sequence population. §Genotypes with borderline significantly higher proportion (0.05<p <0.10) of outbreaks with this transmission mode, when compared to the proportion in the total sequence population. ¶Clusters with significantly higher proportion (p < 0.05) of outbreaks with this transmission mode, when compared to the proportion within the genotype. #Clusters with borderline significantly higher proportion (0.05<p<0.10) of outbreaks with this transmission mode, when compared to the proportion within the genotype. **Genotypes II.1, II.3, II.4 and II.6 were aligned separately for different genomic regions. ††Percentage values <0.5.